R Xie Lab, Lab for Functional Organ-on-a-Chip Engineering and Regeneration Medicine

Publications

Vascularized and Perfusable Human Heart-on-a-Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery

Junyoung Kim, Xuening Zhang, Richard Wang, Adrian Najer, Qiao You Lau, Ana Cammack-Najera, Jang Ah Kim, Yoo Kyung Kang, Ruoxiao Xie, Hyemin Kim, Kai Xie, Hyeonji Lim, Tae-Eun Park, Jinmyoung Joo, Molly M. Stevens*

Advanced Materials

2025

Permanent magnetic droplet–derived microrobots

Yuanxiong Cao#, Ruoxiao Xie#, Philipp W. A. Schönhöfer#, Ross Burdis, Richard Wang,Rujie Sun, Kai Xie1, Jiawen Zou, Xin Song, Qiao You Lau, Junliang Lin, Jang Ah Kim, Dimitar Georgiev, Jiyuan Tang, Ho-Cheung Ng, Olga Bibikova, Yuyang Zuo, Xiangrong L. Lu, Sharon C. Glotzer*, Molly M. Stevens*

Science Advances

2025

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie*

Advanced Healthcare Materials

2025

Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity

Sarah EJ Chambers, Jasenka Guduric-Fuchs, Edoardo Pedrini, Pietro M Bertelli, Chutima Charoensuk, Elisa Peixoto, Varun Pathak, Hamza I Alhamdan, Ruoxiao Xie, Anna Krasnodembskaya, Judith Lechner, Alan W Stitt, Reinhold J Medina*

Angiogenesis

2025

Hyperspectral unmixing for Raman spectroscopy via physics-constrained autoencoders

Dimitar Georgiev, Álvaro Fernández-Galiana, Simon Vilms Pedersen, Georgios Papadopoulos, Ruoxiao Xie, Molly M Stevens*, Mauricio Barahona*

Proceedings of the National Academy of Sciences

2024

Engineered Microfibers for Tissue Engineering

Riguga Su, Yongjian Ai, Jingyu Wang, Lei Wu, Hua Sun, Mingyu Ding, Ruoxiao Xie*, Qionglin Liang*

ACS Applied Bio Materials

2024

A Facile Method to Quantify Synthetic Peptide Concentrations on Biomaterials

Jonathan P Wojciechowski, Thomas Benge, Kaili Chen, Cécile Echalier, Ruoxiao Xie, Molly M Stevens*

ACS Applied Materials & Interfaces

2024

Magnetically driven formation of 3D freestanding soft bioscaffolds

Ruoxiao Xie#, Yuanxiong Cao#, Rujie Sun, Richard Wang, Alexis Morgan, Junyoung Kim, Sebastien J. P. Callens, Kai Xie, Jiawen Zou, Junliang Lin, Kun Zhou, Xiangrong Lu, Molly M. Stevens*

Science Advances

2024

RamanSPy: An Open-Source Python Package for Integrative Raman Spectroscopy Data Analysis

Dimitar Georgiev, Simon Vilms Pedersen, Ruoxiao Xie, Alvaro Fernández-Galiana, Molly M Stevens*, Mauricio Barahona*

Analytical Chemistry

2024

Microfibrous Scaffolds Guide Stem Cell Lumenogenesis and Brain Organoid Engineering

Kaja I Ritzau‐Reid, Sebastien JP Callens, Ruoxiao Xie, Martina Cihova, Daniel Reumann, Christopher L Grigsby, Lino Prados‐Martin, Richard Wang, Axel C Moore, James PK Armstrong, Juergen A Knoblich, Molly M Stevens*

Advanced Materials

2023

Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models

Lei Wu, Yongjian Ai, Ruoxiao Xie, Jialiang Xiong, Yu Wang, Qionglin Liang*

Lab on a Chip

2023

Puffball‐Inspired Microrobotic Systems with Robust Payload, Strong Protection, and Targeted Locomotion for On‐Demand Drug Delivery

Xin Song, Rujie Sun, Richard Wang, Kun Zhou, Ruoxiao Xie, Junliang Lin, Dimitar Georgiev, Andrei‐Alexandru Paraschiv, Ruibo Zhao, Molly M Stevens *

Advanced Materials

2022

Assembly of Fillable Microrobotic Systems by Microfluidic Loading with Dip Sealing

Rujie Sun, Xin Song, Kun Zhou, Yuyang Zuo, Richard Wang, Omar Rifaie‐Graham, David Peeler, Ruoxiao Xie, Yixuan Leng, Hongya Geng, Giulia Brachi, Yun Ma, Yutong Liu, Lorna Barron, Molly M Stevens*

Advanced Materials

2022